Croatian Scientists Tissue Research: New Study Lead by Ana Sunčana Smith

Dr. Ana Sunčana Smith from the Ruđer Bošković Science Institute (IRB) is one more IRB scientist to find herself leading an international scientific team towards new exciting discoveries. Made up of IRB Croatian scientists and Germany’s Friedrich-Alexander University from Erlangen-Nürnberg, Sunčana Smith’s team (the members being Sara Kaliman, Maxime Hubert, Carina Wollnik, Lovro Nuić, Damir Vurnek, Simone Gehrer, Jakov Lovrić, Diana Dudziak, and Florian Rehfeldt) came to a new understanding on the mechanical properties that affect Epithelial Tissue (the form which covers all human bodies).

Their scientific paper titled ”Mechanical Regulation of Epithelial Tissue Homeostasis” has recently been published in the prestigious Physical Review X scientific journal for the study of physics.

As IRB explained in their press release, diseases or injuries to the organism change the elasticity of microcellular surroundings during our lifetime.

”Despite recent efforts to understand homeostasis in epithelial tissues, there are many unknowns surrounding this steady state. It is considered to be regulated by mechanoresponse, but unlike for single cells, this idea remains heavily debated for tissues (…) Our results unequivocally relate the mechanosensitive properties of individual cells to the evolving macroscopic structures, an effect that could be important for understanding the emergent pathologies of living tissues,” reads the abstract of the paper.

While the current researchers focused on a single cell, IRB points out that tissue research like this is scarce.

“This result showed us a more complicated connection between density and cell movability than has been known before. We determined that the organisation of the epithelial tissue is very robust despite great variations in density lead by the various hardness of micro-surrounding. This shows that density is the result of adaptation and that the cell organisation is actively controlled to fulfill its function. This fact can be used in diagnostics, and it has potential implications in understanding the process of epithelial regeneration,” concluded Dr. Ana Sunčana Smith.

This is just one of the great results discovered by IRB, the biggest scientific institute in Croatia. As previously reported, this includes spindle and cell division research, quantum communication development (presented at the G20 Summit), heavy metal analysis in the Adriatic Sea, and much more.

Learn more about Croatian inventions & discoveries: from Tesla to Rimac on our TC page.

For more about science in Croatia, follow TCN’s dedicated page.

 

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